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Contraindicated (1)pentobarbital decreases levels of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Keep away from coadministration with powerful CYP3A4 inducers; these medicine minimize exposure to vandetanib by as much as 40%.pentobarbital will lessen the level or effect of eltrombopag by influencing hepat